A study on the metabolism of lipoic acid and lipoamide.
نویسندگان
چکیده
Reed (1) isolated lipoic acid (LiA) from yeast and liver, and reported that this substance played an important role as one of the coenzymes in the oxidation of ƒ¿-keto acids. Sanadi (2, 3) reported that lipoamide (LiA-NH2), the amide of LiA, had greater activity than LiA as a coenzyme of ƒ¿-ketoglutraric dehy drogenase obtained from heart muscle. The authors (4) studied previously the serum level of LiA in the patients with liver disease, diabetes mellitus, hypertension, arteriosclerosis and polyneuritis. The present study deals with the metabolism of DL-ƒ¿-LiA and DL-ƒ¿-LiA-NH2, using S35-labeled DL-ƒ¿-LiA and DL-ƒ¿-LiA-NH2.
منابع مشابه
Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide.
Thiol-containing compounds, such as glutathione and cysteine, react with selenite under specific conditions to form selenotrisulfides. Previous studies have focused on isolation and characterization of intermolecular selenotrisulfides. This study describes the preparation and characterization of intramolecular selenotrisulfide derivatives of lipoic acid and lipoamide. These derivatives, after s...
متن کاملLipoic acid synthetase deficiency causes neonatal-onset epilepsy, defective mitochondrial energy metabolism, and glycine elevation.
Lipoic acid is an essential prosthetic group of four mitochondrial enzymes involved in the oxidative decarboxylation of pyruvate, α-ketoglutarate, and branched chain amino acids and in the glycine cleavage. Lipoic acid is synthesized stepwise within mitochondria through a process that includes lipoic acid synthetase. We identified the homozygous mutation c.746G>A (p.Arg249His) in LIAS in an ind...
متن کاملMicrosomal lipoamide reductase provides vitamin K epoxide reductase with reducing equivalents.
This study was undertaken to search for the endogenous dithiol cofactor of the reductases of the vitamin K cycle. As a starting point, the redox-active lipophilic endogenous compounds lipoic acid and lipoamide were looked at. The study shows that microsomes contain NADH-dependent lipoamide reductase activity. Reduced lipoamide stimulates microsomal vitamin K epoxide reduction with kinetics comp...
متن کاملThe Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy
Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose sei...
متن کاملComparison of the Effect of Alpha Lipoic Acid (ALA) and Beta-Defensin 1 Protein on Human Sperm Motility and Viability in Different Times of Incubation
Background and Objectives: Antioxidant alpha lipoic acid and β-defensin 1 protein may have a positive effect on the quality of sperm parameters. In this study, the effect of sperm incubation with alpha lipoic acid antioxidant and β-defensin 1 protein were assessed on sperm motility and viability at different times. Methods: In this experimental study, routine semen analysis was carried out o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of vitaminology
دوره 7 شماره
صفحات -
تاریخ انتشار 1961